We continue our critical discussion group meeting series.
This time we have Dr. Shachar Maidenbaum from Columbia university.
The title of his talk is: “Representations of space in human neural oscillations”
Spatial navigation and memory are core activities for humans. The human brain represents spatial features of the surrounding environment (e.g. place, head direction, goal location) and of spatial activity within it (e.g. movement, speed, distance, grid) as part of performing these processes. These signals were previously observed mainly at the micro- and macroscopic level of brain organization. Recently, several mesoscale spatial representations were recorded via Intracranial electroencephalography in human patients, while the patients performed virtual spatial memory tasks. Here I will further explore these representations in humans, focusing on a recent signal we found for grid-like representations, hexadirecitonal modulation of oscillatory power in the theta band (5-8Hz), which is linked to spatial memory. I will present these signals’ anatomical prevalence, theories for their underlying basis and their relation to other levels of neural representation, and the way these signals are modulated by external perceptual input (e.g. navigating virtually with different levels of fog) and by internal idiothetic input (e.g. navigating in the real world with Augmented Reality). I will conclude with discussing how these mesoscale signals bridge the gap between single neuron studies and macroscopic brain signals of spatial navigation and their potential as a mechanistic basis for novel biomarkers and therapeutic targets for diseases causing spatial disorientation or memory impairments.
We will meet at 13:00 in Smith Hall Annex, A-Level, Physics Seminar Room (Rockefeller Uni).
A kosher lunch will be served (Bagels/spreads and coffee), please make sure to register in advance, so we bring enough for everybody!
הפעילות ממומנת ע”י משרד העלייה והקליטה – המרכז לקליטה במדע ואגף יזמות עסקית